2022-RA-727-ESGO Performance of the IOTA ADNEX model in differentiating between benign and malignant adnexal lesions in a Portuguese population

Introduction/Background The Assessment of Different NEoplasias in the adneXa (ADNEX) risk model was developed by clinicians and statisticians from International Ovarian Tumor Analysis (IOTA) group to assist diagnosis ovarian cancer patients who have at least one persistent adnexal tumor are considered require surgery. This study aimed evaluate diagnostic accuracy ADNEX 3 Portuguese tertiary referral centers. Methodology conducted between January 2016 December 2020 included consecutive non-pregnant ≥18-year-old with masses diagnosed our units submitted surgery within 6 months after ultrasound diagnosis. All scans were performed IOTA-certified sonologists. lesions prospectively classified using malignancy threshold set ≥ 10%. By histological classification as main outcome measure, sensitivity, specificity determined for malignant adnexa pathology its subtypes. Results multicenter analysis involved 449 – 345 benign 104 (35 borderline tumors [BOT], 25 stage I, 37 II IV primary 7 secondary metastatic ovary). Sensitivity, (with known CA-125 level all cases) shown accompanying table global specific Regarding frequent misclassified lesions, cystadenoma cystadenofibroma most common entities misinterpreted BOT (39/56), while 5/10 BOTs invasive malignancies another lesions. Only 2/8 correctly classified. Conclusion According data, performance population is similar that previously studied populations. It discriminates well offers fair good discrimination four subtypes malignancy.